TB-500
Also known as: Thymosin Beta-4 fragment, Tβ4 (17–23)
Overview
TB-500 is a synthetic peptide fragment of Thymosin Beta-4, a naturally occurring protein present in virtually all human and animal cells. It has been widely studied for its roles in wound healing, inflammation reduction, and tissue repair. Unlike full-length Thymosin Beta-4, TB-500 consists of the key actin-binding domain believed to drive most of the therapeutic activity.
Mechanism of Action
TB-500 binds to actin monomers, sequestering them and modulating cell migration and differentiation. It promotes angiogenesis, reduces inflammation by downregulating inflammatory cytokines (including IL-6 and TNF-α), and activates satellite cells in muscle. It also upregulates metalloproteinases involved in tissue remodelling and stimulates keratinocyte and endothelial cell migration.