GHK-Cu
Also known as: Copper peptide, Glycyl-L-histidyl-L-lysine copper
Overview
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. First identified in 1973 by Loren Pickart, it has garnered substantial interest for its roles in wound healing, skin remodelling, hair follicle stimulation, and anti-inflammatory activity. Plasma concentrations decline significantly with age, coinciding with reduced tissue repair capacity.
Mechanism of Action
GHK-Cu acts as a potent stimulator of collagen, elastin, glycosaminoglycan, and decorin synthesis in fibroblasts. It modulates over 4,000 human genes — upregulating repair and regenerative pathways while downregulating inflammatory and cancer-related genes. Copper chelation by the peptide facilitates safe copper delivery to tissues. It also stimulates superoxide dismutase (SOD) activity, providing antioxidant protection.