Beginner Fat Loss Protocol: Semaglutide
Overview
A beginner-friendly fat loss protocol centred on semaglutide, designed for those new to GLP-1 peptides who want a structured, conservative approach to sustainable weight loss. This protocol prioritises a slow titration to minimise gastrointestinal side effects and pairs the peptide with evidence-based lifestyle guidance. Suitable for adults with a BMI over 27 who have no contraindications to GLP-1 therapy.
Peptide Stack
| Peptide | Dosage | Frequency | Timing | Duration | Notes |
|---|---|---|---|---|---|
| — | Once weekly | — | — | Inject on the same day each week. Rotate injection sites. |
Cycle Overview
Weeks 1–4: 0.25 mg/week. Weeks 5–8: 0.5 mg/week. Weeks 9–12: 1.0 mg/week (maintenance dose for most users). Optional continuation at 1.0 mg or further titration to 2.4 mg under medical supervision. Minimum cycle: 16 weeks to assess meaningful body composition change. Avoid abrupt discontinuation — taper if stopping.
Stacking Notes
This is a single-peptide protocol. Avoid adding other peptides until you have established your response to semaglutide over at least 4 weeks. Do not combine with other GLP-1 or GIP agonists.
Recommended Bloodwork
Warnings
For research purposes only — not medical advice. Semaglutide is a prescription medicine in the UK. Do not use without appropriate medical oversight. Rapid weight loss can cause gallstone formation. Ensure adequate protein intake (1.6–2.2 g/kg lean mass) and resistance training to preserve muscle mass. Discontinue and seek medical advice if you experience severe abdominal pain.